Fig 1: Effect of E. multilocularis infection on the expression of proteins involved in UPR and ER redox functions.Western blotting and semi-quantitative analysis by densitometry (graphs of densitometry data are shown in S2 Fig) of protein/phospho-protein levels of A) GRP78, B) PERK, eIF2α, p-eIF2α and ATF4, C) ATF6, CHOP, and ERp72, D) IRE1α and p-IRE1α, E) CNX and CRT, and F) H6PD in mock-infected control mice (CTRL), E. multilocularis infected mice (AE), infected mice treated with ABZ (AE-ABZ) or uninfected mice treated with ABZ (ABZ). One representative blot (of two) containing samples from three different mice is shown. Lamin B1 served as loading control. G) Bands corresponding to the respective protein/phospho-protein were analyzed by densitometry (animals per group n = 6). Numbers represent the expression of protein/phospho-protein levels normalized to those of the control (CTRL) group (mean ± SD). Significantly decreased protein/phospho-protein levels are highlighted in red and increased levels in blue. Symbols indicate significant differences (p≤0.05) between groups: *, compared to CTRL; §, compared to ABZ; #, compared to AE-ABZ. No outliers were detected/excluded. Non-parametric, Kruskal-Wallis test followed by Dunn’s Multiple Comparison post-test.